α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester
Scopine Di(2-thienyl) Glycolate
CAS: 136310-64-0
Molecular Formula: C18H19NO4S2
α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester - Names and Identifiers
| Name | Scopine Di(2-thienyl) Glycolate |
| Synonyms | N-DeMethyl TiotropiuM Tiotropium EP Impurity B Scopine-2,2-dithienyl glycolate SCOPINE-2,2-DITHIENYL GLYCOLATE Scopine Di(2-thienyl) Glycolate 2-Thiopheneacetic acid, -hydroxy--2-thienyl-, (1,2,4,5,7) Scopine di(2-thienyl)glycolate scopine-2-dithienyl glycolate 2-thiopheneacetic acid, a-hydroxy-a-2th ( Di(2-thienyl) Glycolate ) (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 2-hydroxy-2,2-dithiophen-2-ylacetate α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester |
| CAS | 136310-64-0 |
| EINECS | 603-953-6 |
| InChI | InChI=1/C18H19NO4S2/c1-19-11-8-10(9-12(19)16-15(11)23-16)22-17(20)18(21,13-4-2-6-24-13)14-5-3-7-25-14/h2-7,10-12,15-16,21H,8-9H2,1H3 |
α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester - Physico-chemical Properties
| Molecular Formula | C18H19NO4S2 |
| Molar Mass | 377.48 |
| Density | 1.48±0.1 g/cm3(Predicted) |
| Melting Point | 138-140°C |
| Boling Point | 542.3±50.0 °C(Predicted) |
| Flash Point | 281.7°C |
| Vapor Presure | 1.37E-12mmHg at 25°C |
| pKa | 10.32±0.29(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.687 |
α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester - Reference Information
| application | scopolamine di (2-thienyl) glycolate is mainly used for the synthesis of tiotropium bromide, such as the transesterification reaction between scopolamine and methyl 2, 2-bis (2-thienyl) glycolate to form 2, 2-bis (2-thienyl) scopolamine glycolate, and finally quaternary ammonium salting reaction with methyl bromide to obtain anhydrous tiotropium bromide; it can also pass 2, 2-bis (2-thienyl) methyl glycolate and scopolol in the presence of sodium metal or sodium methoxide in the molten state of toluene solvent or solvent-free. |
Last Update：2024-04-09 20:49:11
![α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester](http://res.chembk.com/assets/images/structure/136310-64-0.gif)
Supplier List
Spot supply
Product Name: Tiotropium Bromide Impurity 2(Tiotropium Bromide EP Impurity B) Visit Supplier Webpage Request for quotationCAS: 136310-64-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Scopine Di(2-thienyl) Glycolate Request for quotationCAS: 136310-64-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Scopine Di(2-thienyl) Glycolate Request for quotation
CAS: 136310-64-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 136310-64-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: Scopine-2,2-dithienyl glycolate Visit Supplier Webpage Request for quotation
CAS: 136310-64-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 136310-64-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Tiotropium Bromide Impurity 2(Tiotropium Bromide EP Impurity B) Visit Supplier Webpage Request for quotationCAS: 136310-64-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Scopine Di(2-thienyl) Glycolate Request for quotationCAS: 136310-64-0
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Scopine Di(2-thienyl) Glycolate Request for quotation
CAS: 136310-64-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 136310-64-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: Scopine-2,2-dithienyl glycolate Visit Supplier Webpage Request for quotation
CAS: 136310-64-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 136310-64-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History